Custom Peptides
Cayman Chemical Fumarate hydratse-IN-1 10mg
An antiproliferative and anti-inflammatory compound; inhibits proliferation of, and induces ATP depletion in, SW620, ACHN, HCT116, PC3, and SK-MEL-28 cancer cells in the absence, but not in the presence, of glucose in a concentration-dependent manner; reduces the OCR in SW620 cells in the absence of glucose (IC50 = 2.2 µM); preincubation reduces the secreted levels of Ifn-γ, Tnf-α, and granzyme B from mouse CD8+ T cells when cocultured with B16-OVA cells expressing ovalbumin at 25 µM; increases tumor interstitial fluid levels of fumarate, the percentage of apoptotic tumor-associated CD8+ T cells, reduces the levels of tumor-associated CD44+ CD8+ T cells, as well as decreases survival in a B16-OVA murine melanoma model at 25 mg/kg per day
Cayman Chemical CosyntropInacetate 10mg
A synthetic form of ACTH 1-24; increases plasma concentration of hydrocortisone in mares more rapidly and consistently than natural ACTH 1-24
Cayman Chemical cIs10hydroxy NortrIptylIn 10mg
An active metabolite of amitriptyline and nortriptyline; formed from amitriptyline and nortriptyline by CYP2D6; inhibits norepinephrine reuptake in rat cortical slices (EC50 = 160 nM)
Cayman Chemical AlmotrIptnmalate 10mg
An agonist of 5-HT1B and 5-HT1D receptors (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay); selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively); induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries; increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate
Cayman Chemical mthyl alnolnyl Fluorophos 10mg
An analog of MAFP, which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand; pharmacology of the α-linolenyl analog of MAFP has not been completely investigated
Cayman Chemical 2-MethoxyestradIol 10mg
A natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol; has anticancer agent activity as an angiogenesis inhibitor via the HIF-1α pathway; levels are significantly lower in women with severe pre-eclampsia
Cayman Chemical 4AmIno5 bromomethyl2met 10mg
A heterocyclic building block; has been used in the synthesis of vitamin B1 analogs and thiaminephosphoric acid esters
Cayman Chemical PIrarubIcIn 10mg
An anthracycline with anticancer activity; interacts with topoisomerase II; inhibits the growth of human HeLa and C33A cervical, as well as T-24 bladder cancer cells (IC50s = 29, 52, and 36 ng/ml, respectively); inhibits the growth of human Huh7 and MHCC97H liver cancer cells (IC50s = 0.159 and 0.374 μM, respectively); inhibits the growth of mouse M5076 ovarian cancer cells in vitro (IC50 = 0.366 μM) and in vivo in a mouse allograft model at 2 mg/kg for four days
Cayman Chemical RhamnopterIn 10mg
A derivative of biopterin; reduces the incidence of 4-dimethylaminoazobenzene-induced liver tumors in rats at 0.5% in the diet concurrently with 4-dimethylaminoazobenzene; has been used as an internal standard for the quantification of biopterin and neopterin in rat plasma by LC-MS
Cayman Chemical D-Mnoheptulose 10mg
A heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM); blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells
Cayman Chemical DPhe7aMSHtrIfluoroacet 10mg
A peptide derivative of α-MSH and a synthetic intermediate
Cayman Chemical PAMP-12humnmouseratp 10mg
An endogenous fragment and MRGPRX2 agonist; inhibits forskolin-induced cAMP accumulation in CHO cells expressing human MRGPRX2 (EC50 = 57.2 nM); selectively induces calcium mobilization in CHO cells expressing MRGPRX2 (EC50 = 41 nM) over those expressing MRGPRX1, MRGPRX3, or MRGPRX4 at 1 µM; an antagonist of nAChRs that inhibits carbachol-induced catecholamine release (IC50 = 1.3 µM) and calcium and sodium influx (IC50s = 0.39 and 0.87 µM, respectively), but not histamine-induced catecholamine release or calcium and sodium influx (IC50s = >1 µM for all), in primary bovine adrenal chromaffin cells; reduces mean arterial blood pressure in normotensive rats at 10 to 50 nmol/kg
Cayman Chemical R-Metalaxyl-d6 10mg
An internal standard for the quantification of (R)-(−)-metalaxyl by GC- or LC-MS